We have licenced two very important components that we plan to combine to form a range of therapies aimed at treating serious inflammatory diseases.
By combining these two important components to form its lead compound JEL3108, a new medicine to more safely and effectively treat the life threatening and disabling inflammatory diseases such as inflammatory bowel disease (IBD), atopic dermatitis and burns.
Bridge Biotec’s novel medicines are short proteins (“peptides”) that can be delivered into the human cell using a patented safe nano-polymer delivery technology. These short peptides, that will be broken down into simple and naturally occurring amino acids, are highly active and exquisitely specific inflammation blockers, so only tiny doses will be required to more safely and effectively treat serious inflammatory diseases.
Our portfolio is focused on developing these novel peptide anti-inflammatories to more safely and effectively treat serious inflammatory diseases such as inflammatory bowel diseases (IBD), atopic dermatitis (AD) and burns.
Bridge Biotec will direct the lead program and provide a backup portfolio which significantly de-risks the further development of the lead project while supporting similar future drug developments.
Inflammation is a normal physiological response to a range of harmful stimuli such as irritation, tissue damage or infection and is characterised by redness, swelling and discomfort (pain or itch). Inflammation is part of the body’s innate immune response and usually clears up. However, in some circumstances the inflammatory response does not resolve spontaneously, resulting in chronic inflammation that is the underlying cause of a number of serious inflammatory diseases. We are developing new therapies that more safely and effectively treat such diseases using potent peptides targeted to key mechanisms in inflammation.
We utilize a highly effective drug delivery system based on a well-described nano-polymer with over 30 years of safe human use. This system rapidly self-assembles with our peptides and “packages” them into nanoparticles. These nanoparticles greatly enhance intracellular delivery into mammalian cells.
Use of this technology allows Bridge Biotec to develop therapies against a well-validated target in new ways. It also lets us over-come the limitations of some current therapies by improving drug solubility, cellular delivery and efficacy. Finally, the ability of our nanopolymer system to deliver our peptides in active form into cells opens up exciting new possibilities for “intracellular biologics” capable of tackling attractive approaches to disease treatment that are currently perceived to be “undruggable” by conventional small molecule treatments.
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